The series follows Ewan and Charley as they journey through Latin America including the countries of Argentina, Chile, Bolivia, Peru, Ecuador, and up through Colombia, Central America - Panama, Costa Rica, Nicaragua, Honduras, Guatemala - and Mexico, before entering the United States and finishing in California. They were supported by diesel powered vehicles and generators and back up bikes. Cars and motorcycles were charged at charging points built especially for the journey by Rivian.

The production team followed Ewan and Charley’s route in prototype Rivian electric trucks built especially for the journey. Also joining is associate producer Taylor Estevez and cinematographer Anthony Von Seck. Accompanying Ewan and Charley are the same key team members from Long Way Round and Long Way Down, including director/producers David Alexanian and Russ Malkin and directors of photography Jimmy Simak and Claudio Von Planta. They rode Harley-Davidson LiveWire electric motorcycles manufactured by Harley-Davidson that had been converted into adventure bikes. The journey covered 13,000 miles, through 13 countries over 100 days starting on 5 September 2019 and finishing on 14 December 2019.

The first three episodes of Long Way Up premiered globally on Apple TV+ on Friday, 18 September 2020, and eight further episodes aired weekly through to 13 November 2020. It is a follow-up to 2004's Long Way Round where the pair rode from London to New York and then again in 2007 Long Way Down, when they rode south from John o' Groats in Scotland through eighteen countries in Europe and Africa to Cape Town in South Africa. Long Way Up is a British television series which debuted 18 September 2020, documenting a motorcycle journey undertaken in 2019 by Ewan McGregor and Charley Boorman, from Ushuaia in Argentina through South and Central America to Los Angeles in the United States.

Charley boorman long way round